Description
Three amino acids. Calmed inflammation head to toe.
KPV is a tripeptide (Lysine-Proline-Valine) that represents the C-terminal fragment of the alpha-MSH hormone. It is a potent anti-inflammatory and antimicrobial peptide with applications across inflammatory bowel disease, skin conditions, mast cell activation, and wound healing. KPV works locally at the site of inflammation and carries an excellent safety profile across delivery routes.
How It Works
- Reduces inflammation — Modulates NF-κB and inflammatory cytokine signaling.
- Antimicrobial action — Active against various pathogens including candida.
- Stabilizes mast cells — Reduces mast cell over-activation and histamine release.
- Supports wound healing — Accelerates tissue repair.
- Immunomodulatory — Balances immune responses without broadly suppressing them.
- Multi-route effective — Works orally (gut), topically (skin), or by injection (systemic).
What It’s Used For
Inflammatory bowel disease: Ulcerative colitis, Crohn’s disease, gut inflammation.
Skin conditions: Eczema, psoriasis, rosacea, acne, wound healing.
Mast cell activation: MCAS, histamine intolerance, environmental sensitivities.
Autoimmune inflammation: Adjunct in various autoimmune skin and gut conditions.
Chronic inflammation: Systemic inflammatory load, chronic pain.
Wound care: Chronic wounds, post-surgical healing support.
Dosing & Protocol
- Delivery — Oral capsule, topical cream, or subcutaneous injection
- Standard dose — 200–500 mcg daily (oral); topical applied 1–2x daily
- Timing — With or without food; consistent daily use
- Duration — 8–12 weeks minimum for anti-inflammatory effects
- Best paired with — Omega-3s, curcumin, gut-healing support
- Onset — Skin effects visible in 2–6 weeks; gut effects in 4–8 weeks
- Administered by — Self-administered at home; prescribed by Dr. Thomas
What Patients Report
- Reduced inflammation and pain
- Calmed skin conditions
- Reduced gut inflammation and symptoms
- Fewer histamine and allergic reactions
- Improved wound healing
- Better systemic tolerance to triggers
- Reduced flares of chronic conditions
Safety & Pharmacy Notes
KPV has an excellent safety profile across all delivery routes.
- Possible mild effects: mild GI upset with oral use, or rare skin irritation with topical use.
- Not recommended in pregnancy or breastfeeding without provider approval.
- Not a substitute for prescribed IBD medications.
- Dispensed through licensed 503A compounding pharmacies.
- An initial consultation with Dr. Thomas is required before starting therapy.
