Description
0.5mg capsules 60 day supply
A gate for a gut that has forgotten how to close.
Larazotide (also known as AT-1001) is an eight-amino-acid peptide that acts as a zonulin antagonist. Zonulin is the molecule your body uses to open the tight junctions of your intestinal wall — and when that system dysregulates, the result is what is often called leaky gut, where undigested particles, toxins, and bacterial fragments pass into the bloodstream. Larazotide helps restore the integrity of those tight junctions and supports gut barrier function.
How It Works
- Blocks zonulin activity — Prevents zonulin from opening intestinal tight junctions.
- Restores barrier integrity — Tightens intestinal wall permeability.
- Reduces systemic inflammation — Less translocation of inflammatory triggers into the bloodstream.
- Supports autoimmune modulation — Addresses the leaky-gut mechanism common to many autoimmune conditions.
- Local action — Works directly in the gut lumen with minimal systemic absorption.
- Amplifies gut-healing protocols — Complements diet and lifestyle changes.
What It’s Used For
Leaky gut syndrome: Increased intestinal permeability, multiple food sensitivities.
Celiac disease: Adjunct support for accidental gluten exposure.
Autoimmune conditions: Hashimoto’s, RA, lupus, MS — addressing the gut-barrier component.
IBS & functional gut disorders: Post-infectious IBS, symptoms tied to permeability.
Food sensitivities: Multiple food intolerances linked to gut integrity.
Long-haul recovery: Post-COVID gut dysfunction.
Dosing & Protocol
- Delivery — Oral capsule, taken before meals
- Standard dose — 0.5–1 mg before each meal (2–3x daily)
- Timing — 15 minutes before meals for optimal effect
- Duration — 2–6 months of active use, then reassessment
- Best paired with — Gut-healing protocol, elimination diet, L-glutamine, zinc carnosine
- Monitoring — Zonulin levels, food sensitivity panels, symptom tracking
- Administered by — Self-administered at home; prescribed by Dr. Thomas
What Patients Report
- Reduced bloating and GI symptoms
- Better tolerance of previously reactive foods
- Reduced brain fog after eating
- Improved energy and less post-meal fatigue
- Better joint comfort in autoimmune patients
- Reduced skin flares (eczema, psoriasis)
- Overall systemic inflammation reduction
Safety & Pharmacy Notes
Larazotide is generally very well tolerated with minimal side effects. Its minimal systemic absorption means it acts mostly locally in the gut.
- Possible mild effects: initial constipation as gut motility rebalances, occasional headache.
- Not recommended in pregnancy or breastfeeding without provider approval.
- Not a replacement for a gluten-free diet in celiac disease.
- Dispensed through licensed 503A compounding pharmacies.
- An initial consultation with Dr. Thomas is required before starting therapy.
